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Ketamine is used by medical practitioners and veterinarians as an anesthetic.  ketamine liquid for sale, It’s sometimes used illegally by people to get high. Ketamine is a dissociative drug, which means it acts on different chemicals in the brain to produce visual and auditory distortion and a detachment from reality. Order now

Pharmacology of Ketamine

Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, and it blocks HCN1 receptors. However, at higher doses, it may also bind to the opioid mu and sigma receptors. It disrupts the neurotransmitter (brain chemical) glutamate. Glutamate is involved with learning, memory, emotion, and pain recognition. It can exhibit sympathomimetic activity which can lead to rapid heart rate and elevated blood pressure.

This agent is a lipid-soluble compound, and has an initial rapid distribution and large volume of distribution, with a half-life of 10 to 15 minutes. Secondarily, the drug distributes into peripheral tissues with a slower elimination half-life of up to 3 hours, undergoes hepatic metabolism, and is excreted in the urine.

How is it used?

Ketamine can be swallowed, snorted or injected. It’s also sometimes smoked with cannabis or tobacco. The effects of ketamine may be experienced within one minute if injected, 5–15 minutes if snorted, and up to 30 minutes if swallowed. Its effects can last for around an hour, however, an individual’s coordination or senses may be affected for up to 24 hours after initial use.4

Why is Ketamine Used Medically?

• Ketamine can provide pain relief and short-term memory loss (for example, amnesia from a medical procedure).
• In surgery, it is used as an induction and maintenance agent for sedation and to provide general anesthesia.
• It has also been used for pain control in burn therapy, battlefield injuries, and in children who cannot use other anesthetics due to side effects or allergies.
• Ketamine, through blocking at the N-methyl-D-aspartate (NMDA) site, has rapid action in controlling symptoms of depression and acute suicidal ideation.
• At normal doses, it is often preferred as an anesthetic in patients at risk of bronchospasm and respiratory depression.